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On January 5, 2021, JACS journal published a research article by scientists from the University of California, San Francisco, invented an antibody-based PROTAC technology, and verified its feasibility with the PD-L1 target as an example. The research means that PROTAC can be used in the form of antibodies to extend the target to cell surface proteins. PROTAC is the full name PROteolysis TArgeting Chimera. It is a bifunctional small molecule. One end is a ligand that binds to the target protein, and the other end is a ligand that binds to E3 ubiquitin ligase. This bifunctional small molecule can bring the target protein and E3 enzyme closer together, so that the target protein is labeled with ubiquitin, and then degraded through the ubiquitin-proteasome pathway. This article by JACS converts PROTAC from a small molecule form to an antibody form, namely AbTAC. AbTAC is a double antibody in form. One side specifically binds to membrane-linked E3 ubiquitin ligase (RNF43), and the other side specifically binds to the target protein.